Intracellular hydrogen peroxide produced by 6-hydroxydopamine is a trigger for nigral dopaminergic degeneration of rats via rapid influx of extracellular Zn2+

Ryusuke Nishio,Hiroki Morioka,Azusa Takeuchi,Nana Saeki,Ryo Furuhata,Misa Katahira,Takato Chinenn,Haruna Tamura,Haruna Tamano,Atsushi Takeda

NeuroToxicology（2022）

引用 4|浏览5

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摘要

•6-OHDA taken up through dopamine transporters produces H2O2 in dopaminergic neurons.•H2O2 is retrogradely transported to presynaptic glutamatergic terminals.•H2O2 activates TRPM2 channels and glutamate accumulates in the extracellular compartment.•H2O2 induces intracellular Zn2+ dysregulation via AMPA receptor activation.•Zn2+ dysregulation results in dopaminergic degeneration prior to movement disorder.

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关键词

Hydrogen peroxide,TRPM2 cation channel,Zn2+,Dopaminergic neuron,Substantia nigra,6-OHDA,Parkinson's disease

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