N-methyl-d-aspartate Receptor-mediated Preconditioning Mitigates Excitotoxicity in Human Induced Pluripotent Stem Cell-derived Brain Organoids

Hanke Gwendolyn Bauersachs,C. Peter Bengtson,Ursula Weiss,Andrea Hellwig, Celia García-Vilela, Bastienne Zaremba,Henrik Kaessmann,Priit Pruunsild,Hilmar Bading

Neuroscience（2022）

引用 7|浏览8

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摘要

•NMDA receptors mediate glutamate excitotoxicity in human iPSC-derived brain organoids.•Brain organoid excitotoxicity involves structural disintegration and CREB shut-off.•Preconditioning with NMDA boosts synaptic activity and cell survival in organoids.

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关键词

AMPA,BB,BSA,CRE,CREB,ECL,GABAA,iPSC,LDH,NM,NMDA,NMDAR,MM,PBST,pCREB,SEM,sEPSC,sIPSC,snRNA-seq,sPSC,TBP,TEM

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