Feline Leukemia Virus-B Envelope Together With its GlycoGag and Human Immunodeficiency Virus-1 Nef Mediate Resistance to Feline SERINC5

Lucía Cano-Ortiz,Qinyong Gu,Patricia de Sousa-Pereira,Zeli Zhang, Catherina Chiapella,Augustin Penda Twizerimana,Chaohui Lin,Ana Cláudia Franco,Sue VandeWoude,Tom Luedde,Hanna-Mari Baldauf,Carsten Münk

Journal of Molecular Biology（2022）

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摘要

•HIV-1 resists feline and human SERINC5 by its NEF protein.•FIV is sensitive to feline and human SERINC5 and has no viral counteractor.•FeLV has two determinants that counteract SERINC5: glycoGag and envelope protein.•FeLV-B envelope can protect HIV-1Δnef or FIV against SERINC5.

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关键词

SERINC5,restriction factors,glycoGag,HIV-1,FIV

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