A characteristic feature of the skin blistering disease epidermolysis bullosa simplex (EBS) is keratin filament (KF) network disassembly leading to aggregation of the basal epidermal keratin type II (KtyII) K5 and its type I partner keratin

Mugdha Sawant, Nicole Schwarz, Reinhard Windoffer, Thomas Magin, Jan Krieger, Norbert Mücke, Boguslaw Obara , Vera Jankowski, Joachim Jankowski, Verena Wally, Thomas Lettner, Julia Reichelt, Rudolf E. Leube 1 Institute of Molecular and Cellular Anatomy, RWTH Aachen University, Aachen, Germany 2 Institute of Biology and Translational Center for Regenerative Medicine, University of Leipzig, Leipzig, Germany 3 Biophysics of Macromolecules, German Cancer Research Center, Heidelberg, Germany 4 School of Engineering and Computing Sciences, Durham University, Durham, UK 5 Institut für Molekulare Herz-Krauslaufforschung, RWTH Aachen University, Aachen, Germany 6 EB House Austria, University Hospital Salzburg, Salzburg, Austria Correspondence: