X-linked agammaglobulinemia and COVID-19: Two case reports and review of literature

COVID-19 has caused a global crisis, infecting millions, and mainly manifesting with mild to moderate symptoms. The severity of disease occurred in a minority of those with comorbidities, who had an enhanced rate of disease progression and death. We present two case reports of adolescents with XLA from the state of Kerala in South India who were infected by SARS-CoV-2 and recovered without the need for artificial ventilation or convalescent plasma. In both the patients, the diagnosis of XLA had been confirmed with whole-exome sequencing. Rapid antigen tests for SARS-C0V-2 remained positive for more than two weeks in both cases. However, no post-COVID illness or re-infection has been reported in either patient. We have also reviewed all the cases with XLA infected by SARS-CoV-2 to date.