Genetic and environmental determinants of stressful life events and their overlap with depression and neuroticism: [version 2; peer review: 1 approved, 2 approved with reservations]

Toni-Kim Clarke,Yanni Zeng,Lauren Navrady,Charley Xia,Chris Haley,Archie Campbell,Pau Navarro,Carmen Amador,Mark Adams,David M. Howard, Aleix Arnau Soler,Caroline Hayward,Pippa A. Thomson,Blair H. Smith,Sandosh Padmanabhan,Lynne J. Hocking,Lynsey S. Hall,David J. Porteous,Ian J. Deary,Andrew M. McIntosh

Wellcome Open Research（2018）

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摘要

Background: Stressful life events (SLEs) and neuroticism are risk factors for major depressive disorder (MDD). However, SLEs and neuroticism are heritable and genetic risk for SLEs is associated with risk for MDD. We sought to investigate the genetic and environmental contributions to SLEs in a family-based sample, and quantify genetic overlap with MDD and neuroticism. Open Peer Review

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