Salivary β2- microglobulin Levels in Patients with Oral Lichen Planus and Squamous Cell Carcinoma

Objectiveβ2 microglobulin one of the biomarkers which are used to oral malignancy and pre-malignance lesion diagnosis. The components of the microglobulin system can help in growing and development of tumors directly or indirectly. The current study aims to evaluate the salivary β2- microglobulin level in malignance and pre-malignance lesion. The statistical population of research consists of 75 people which 25 people were healthy, 25 were infected by oral Lichen Planus (OLP) and remaining were infected by squamous cell carcinoma (SCC). The salivary data was performed by none –stimulated spitting method. The sample was performing during 9-12 AM and samples were transmitted to the laboratory immediately and salivary beta2microglobin was recorded based on the factory instructions by ELISA optical density method with 45Nm wavelength for each sample. Data analysis was performed by SPSS 24 software and ANOVA and post-hoc least significant difference (LSD) test.ResultsThe salivary β2 microglobulin level in squamous cell carcinoma (SCC) and oral lichen plan (OLP) patient is significantly higher than the healthy group. Therefore, we can use this index as a modern treatment protocol for malignancy and a pre-malignance oral lesion.