Cannabis

There is relatively little evidence around the role of cannabis and cannabinoids in the treatment of pediatric pain, leading to a reliance on limited adult research that may or may not be relevant. In this chapter, we discuss the science behind cannabinoid receptors, current indications for cannabis and cannabinoid use and associated risks, evolving evidence around their use in pain medicine, and particular considerations of treatment in children. We present a hypothetical clinical scenario to more clearly set the stage for addressing these considerations in adolescents. Finally, we discuss important points for researchers and clinicians to examine as they weigh the risk and benefit of treatment in a world where cannabis and its derivatives are available, evidence-based, and sought-after options for various conditions related to pediatric chronic pain.