Evaluation of psychometric properties of the patient-reported outcomes measurement information system physical function 10-item short form in systemic lupus erythematosus

no differences motor coordination, supporting an anxiety phenotype leading to decreased movement in the open field. On novel object placement testing, there were no differences in time spent with the novel object. Lastly, the forced swim test revealed that B6.Nba2 mice spent more time immobile than B6 mice (p<0.02), suggesting a depressive-like behavior in B6. Nba2 mice. Conclusions Our data suggest that the B6.Nba2 mouse model expresses a strong anxiety phenotype, a depressive phenotype, but no deficits in spatial memory. This observation warrants further exploration of the B6.Nba2 as a mouse model of NPSLE along with analyses of brain histology and morphology and future evaluations of the relationship between IFN-, autoantibody levels and neurological disease manifestations. Funding Source(s): None