Development of custom Surface Plasmon Resonance Au biosensor for liver cancer biomarker detection

•Innovative customized biosensor for alpha-fetoprotein biomarker detection.•Our strategy is based on a sandwich immune recognition configuration.•Plasmonic Au biosensor developed reached a sensibility in picomolar range.•Regeneration of the Au biosensor allows to have reproducibility in the results.•Our label free plasmonic biosensor represents new diagnostic tools in point of care.