An unexpected therapeutic effect of isosorbide dinitrate on challenging chronic tracheobronchitis

Two patients have suffered from chronic tracheobronchitis for twenty years and were treated by traditional therapy. However, chronic tracheobronchitis has never been completely cured. They develop lasting drastic morning coughing because of throat abnormal sensation caused by sticky phlegm. The chronic tracheobronchitis was obviously relieved, in most conditions was totally disappeared, since the third month they regularly took isosorbide dinitrate (ISDN) for angina pectoris. This unexpected effect of ISDN is remarkable, and given the smooth muscle relaxation mechanism, this may provide a potential therapeutic idea that takes advantage of similar drugs both for angina pectoris and chronic tracheobronchitis.