Clustering of Parkinson Subtypes: Strong Influence of D2 Receptor Polymorphism and Gender

Abstract Next to motor and non-motor symptoms some more basic features are relevant in idiopathic Parkinson’s disease subtype classification influencing basal ganglia circuitry via dopamine receptor polymorphism and gender dimorphism. By kmeans-clustering algorithm we found an influence of D2 receptor polymorphism and gender on treatment response to dopaminergic drugs -reflected by daily levodopa dosage- opening the door for a more personalized individual therapy in idiopathic Parkinson’s disease.