Reflections on the scientific method in medicine

1. Background 1.1. The Approach to a Scientific Method in Clinical Medicine 1.2. How the Current Situation Developed 2. Essential methodological principles 3. Logical and methodological problems of clinical medicine science 4. Suggestions to improve medical scientific methodology 4.1. Creation of an Integrative Medical Scientific Methodology 4.2. Use of a “Recombinant” Hypothesis-Discovery Support System 4.3. Use of a Modeling and Simulation Research Design Optimizer 4.4. Enhancement of Clinical Scientific Hypothesis Creativity 5. Underlying theoretical and philosophical problems of medical science 6. Unified methodological system for investigation in medicine 6.1. A Trans-methodological Model of Clinical, Basic and Health Sciences 6.2. Re-unification of Clinical Scientific Method for Practice and Research 7. Conclusions and Recommendations Acknowledgments Glossary Bibliography Biographical Sketch