Healthy myeloid-derived suppressor cells express the surface ectoenzyme Vanin-2 (VNN2)

David C Soler,Amber Kerstetter-Fogle,Andrew B Young,Pat Rayman,James H Finke, Sarah M Debanne,Kevin D Cooper,Jill Barnholtz-Sloan,Andrew E Sloan,Thomas S McCormick

Molecular Immunology（2022）

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摘要

•Several novel surface proteins were identified in monocytic MDSC from healthy patients.•Monocytic MDSC present in healthy patients express high levels of the surface VNN2 ectoenzyme.•VNN2 levels decrease in monocytic MDSC present in high-grade glioma patients.•VNN2 might work as a circuit breaker to rein in monocytic MDSC immunosuppressive functions.

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关键词

Immunosuppression,Mo-MDSC,VNN2,GPI-80

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