Running title : CO 2 regulation mechanisms of SLAC 1 channel Reconstitution of CO 2 regulation of SLAC 1 anion channel and function of CO 2-permeable PIP 2 ; 1 aquaporin as carbonic anhydrase 4 interactor

Division of Biological Sciences, Section of Cell and Developmental Biology, University of California, San Diego, La Jolla, CA 92093-0116, USA. College of Life Science and Technology, Huazhong Agricultural University, No.1, Shizishan Street, Hongshan District Wuhan, 430070, China. Department of Physiology and Biophysics, Case Western Reserve University, OH 44106, USA. Physics Department, University of California, San Diego, La Jolla, CA 92093, USA.