THROMBOSIS AND HEMOSTASIS Structural and functional characterization of a speci fi c antidote for

Andrew Buchanan, Philip Newton,Susanne Pehrsson,Tord Inghardt, Thomas Antonsson,Peder Svensson,Tove Sjögren, Linda Öster, Annika Janefeldt, Ann-Sofie Sandinge,Feenagh Keyes,Mark Austin,Jennifer Spooner,Peter Gennemark, Mark Penney, Garnet Howells, Tristan Vaughan,Sven Nylander

semanticscholar（2015）

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摘要

• In the clinic, all oral antiplatelet medicines have a risk of bleeding complications. • We present an antidote for ticagrelor that reverses its antiplatelet effect in human platelet-rich plasma and its bleeding effect in mice. Ticagrelor is a direct-acting reversibly binding P2Y12 antagonist and is widely used as an antiplatelet therapy for the prevention of cardiovascular events in acute coronary syn-

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