P1‐354: withdrawn

1.89 to 87.12), compared to right temporal WMH (OR1⁄4 10.26, c2(6) 1⁄4 5.27, p 1⁄4. 02 95%CI: 1.45 to 72.42). Frontal, parietal and occipital WMHs were not associated with GLB in mild AD. In controls, GLBwas not associated with regionalWMH. Temporal WMH did not interact with total temporal or medial temporal grey matter after controlling for covariates (p>.05). Conclusions:CVD is a major risk factor for GLB in patients with mild AD, independent of global neurodegeneration. Specifically, WMH localized in the left temporal region exhibited the largest risk, and right temporal WMH exhibited a high but smaller comparative risk. An association between WMH and GLB was only observed in mild AD, compared to controls, indicating that a critical level of cerebral atrophy may be required before WMH impacts GLB. These findings support the role of WMH in the diagnostic evaluation for GLB and also intervention strategies to reduce GLB by treating CVD.