Role of heterozygous and homozygous alleles in cryptochrome-deficient mice

Yoshiaki Oda,Nana N. Takasu,Sachi N. Ohno,Yukie Shirakawa,Mitsutaka Sugimura,Takahiro J. Nakamura,Wataru Nakamura

Neuroscience Letters（2022）

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摘要

•Cry1−/− mice had shorter circadian period, compared to WT mice.•Cry2−/− mice had longer circadian period, compared to WT mice.•Period length was not altered in Cry1+/− mice, suggesting functional compensation.•Period length in Cry2+/− mice was longer than WT mice.•Results indicate a haploinsufficiency for Cry2 in generating circadian rhythms.

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关键词

Circadian rhythm,Suprachiasmatic nucleus,Pituitary gland,Clock genes,Cryptochrome,Wheel-running activity

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