Porous Nanohybrid Membranes Promotes Niches

21 Despite the attention given to the development of novel responsive implants for 22 regenerative medicine applications, the lack of integration with the surrounding tissues 23 and the mismatch with the dynamic mechanobiological nature of native soft tissues 24 remain in the current products. Hierarchical porous membranes based on a poly (urea25 urethane) (PUU) nanohybrid have been fabricated by thermally-induced phase 26 separation (TIPS) of the polymer solution at different temperatures. Thermoresponsive 27 stiffness softening of the membranes through phase transition from the semicrystalline 28 phase to rubber phase and reverse self-assembling of the quasi-random nanophase 29 structure was characterized at body temperature near the melting point of the crystalline 30 domains of soft segments. The effects of the porous structure and stiffness softening on 31 proliferation and differentiation of human bone-marrow mesenchymal stem cells (hBM32