Author’s response to reviews Title: A rare missense variant in APC interrupts splicing and causes AFAP in two Danish families Authors:

Title: A rare missense variant in APC interrupts splicing and causes AFAP in two Danish families Authors: Malene Djursby (malene.djursby@regionh.dk) Karin Wadt (karin.wadt@regionh.dk) Jane Hübertz Frederiksen (jane.huebertz.frederiksen@regionh.dk) Majbritt Busk Madsen (majbritt.busk.madsen.01@regionh.dk) Lukas Adrian Berchtold (lukasadrianberchtold@gmail.com) Jane Preuss Hasselby (jane.preuss.hasselby@regionh.dk) Gro Linno Willemoe (gro.linno.willemoe.02@regionh.dk) Thomas van Overeem Hansen (thomas.van.overeem.hansen@regionh.dk) Anne-Marie Gerdes (anne-marie.gerdes@regionh.dk) Version: 1 Date: 02 Mar 2020 Author’s response to reviews: Copenhagen, Feb 28, 2020