Temporal and Spatial Dynamics of Hepatic Stellate Cell Activation in Intrahepatic Cholangiocarcinoma Short Title: Hepatic Stellate Cell in Cholangiocarcinoma

Cheng Tian, Liyuan Li, Qingfei Pan, Yizhen Li, Wentao Yang, Li Fan, Anthony Brown, Michelle Morrison, Kaushik K. Dey, Eric J. Norris, Jun J. Yang, Jiyang Yu, Evan S. Glazer, and Liqin Zhu Department of Pharmacy and Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee, United States Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, Tennessee, United States Departments of Surgery and Cancer Center, College of Medicine, The University of Tennessee Health Science Center, Memphis, Tennessee, United States STEMCELL Technologies, Brentwood, Tennessee, United States * Equal contribution