' s response to reviews Title : 118 SNPs of Folate-Related Genes and Risks of Selected Congenital Anomalies

This paper presents an important and very work-consuming study with a bit disappointed results. All possible candidate gene polymorphisms in the origin of NDT and conotruncal cardiac defects were checked without the detection and/or confirmation strong association. Nevertheless this study is an important, though mainly negative step in the route of understanding better the etiology of two most important structural birth defects in the human being. I addition the detailed presentation of their laboratory analyses may help others to use their data for meta-analysis or to look for new directions.