Risk factors for progression of solitary plasmacytoma of bone to multiple myeloma in the spine: A population-based study

Background: Spine SBP is a primary spinal malignant tumor. Risk factors associated with progression of solitary plasmacytoma of bone (SBP) to multiple myeloma in spine remains unknown. This study therefore aimed to identify the risk factors associated with progression of solitary plasmacytoma of bone (SBP) to multiple myeloma in the spine.Methods: Data of 1543 patients diagnosed with spine SBP between 1992 and 2013 was obtained from the Surveillance, Epidemiology, and End Results (SEER) database for analysis. Risk factors associated with progression of SBP to multiple myeloma (MM) were then identified using univariate and multivariate regression analysis methods.Results: Out of the 1543 patients diagnosed with spine SBP, 659 of them progressed to MM. The overall rate of progression to MM was 42.51%. Univariate and multivariate regression analysis revealed that age, race, gender and chemotherapy were independent risk factors associated with SBP progression to MM.Conclusion: Old aged patients, patients belonging to the white race, female patients and those undergoing chemotherapy were identified to be at a high risk of progression to MM. This information will assist clinicians in evaluating patients’ risk of SBP progression to MM at the point of diagnosis and advise them accordingly.