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Efficient Manufacturing Process for the Selective Estrogen Receptor Degrader GDC-9545 (giredestrant) Via a Crystallization-Driven Diastereoselective Pictet–Spengler Condensation

Jie Xu,Cheol K. Chung,Andrew McClory,Kyle A. Mack, Michael E. Dalziel,Alec Fettes,Kyle Clagg,Ngiap-Kie Lim,Georg Wuitschik,Christian Jenny, Laure Finet,Michael Kammerer,Haiming Zhang,Remy Angelaud,Francis Gosselin

ORGANIC PROCESS RESEARCH & DEVELOPMENT（2022）

Cited 6|Views0
Key words
Pictet-Spengler reaction,Buchwald-Hartwig C-N coupling,oligomers
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