Catalyst-free synthesis of α,α-disubstituted carboxylic acid derivatives in ambient conditions via Wolff rearrangement

Herein, a hexafluoroisopropanol (HFIP)-promoted wolff rearrangement reaction was developed, delivering variousα,α-disubstituted carboxylic acid derivatives in good to excellent yields. In this reaction, α-diazoketone could be activated by HFIP under mild...