Results of a randomized clinical trial

Objective: The Nano-OligoSaccharide Factor (NOSF) is a new compound aiming to promote wound closure mainly through inhibition of MMPs activity. This factor is incorporated within a lipido-colloid matrix (TLC-NOSF matrix) and locally released in the wound. The objective of this study was to document the performance of the NOSF relative to a matrix containing collagen and oxidized regenerated cellulose (ORC) effect, in the local management of venous leg ulcers (VLU).