Real-time cryo-EM structure determination for drug discovery

Single particle cryo-EM (cryo-electron microscopy) allows high-resolution imaging of macromolecular complexes in close-to-native state, at near-atomic resolutions. This provides a revolutionary new source of structural information for drug discovery. As cryo-EM based drug discovery efforts evolve and develop, there is a strong need for powerful methods and robust tools that enable the entire workflow of cryo-EM data collection and data processing to fit within the timelines that are relevant in drug discovery.