Board # 284 June 2 11 : 00 AM-12 : 30 PM Relationship Between Oxygen Consumption , Percentage Of Muscle Mass And Risk Of Cardiovascular Disease In Adult Men

METHODS Thirty college-aged, women were randomly assigned to an intervention (N=15; 31.5 ± 5.6 kg/m2; 21.6 ± 3.3 yrs) or control (N=15; 30.8 ± 5.8 kg/m2; 21.5 ± 3.1 yrs). The intervention included weekly face-to-face meetings to reduce BPA exposures from food, cosmetics, and other packaged products. Women were provided with BPAfree cosmetics, hygiene, glass food/water containers and daily self-monitored major sources of BPA. Fasting urine BPA and creatinine concentrations, and weight were assessed at baseline and after 3-weeks. RESULTS BPA was non-detectable (limit of detection 0.05 μg/L) in 26% of samples at baseline. No significant (P=0.55) treatment x time interaction effect was observed on creatinine-adjusted BPA concentrations from baseline to 3-weeks in the intervention (0.41 ± 0.56, 0.77 ± 0.66 μg/g Creatinine) or control group (0.62 ± 0.92, 0.51 ± 0.81 μg/g Creatinine) using baseline BMI, age, and demographics as covariates. No significant treatment x time interaction effect (P=0.54) in weight was observed from baseline to 3weeks in the intervention (83.9 ± 17.0, 83.9 ± 16.9 kg) or control group (81.4 ± 15.4, 81.1 ± 15.6 kg), and changes in creatinine-adjusted-BPA concentrations and weight were not significantly related (P>0.05). In sensitivity analysis, omitting subjects with non-detectable BPA concentrations at baseline, there was a trend for a significant treatment x time interaction (P=0.09). CONCLUSION 3-week intervention had no effect on urinary BPA concentrations or weight in women with obesity. Future research is needed to examine intervention effects in individuals with high baseline urine BPA.