Structure variability and phylogeny of Klebsiella pneumoniae OXA-48 Class D carbapenemases

Carbapenem antibiotics are considered last resort options in the treatment of infections caused by multidrug-resistant Enterobacteriaceae producing Extended Spectrum β-Lactamases (ESBLs). The emergence of Klebsiella pneumoniae OXA-48 in particular is steadily expanding and represents a major public health concern. The aim of the present study is to analyze the variability and phylogeny of K. pneumoniae OXA-48 amino acids structures from different geographic areas of the world. Structure variability and phylogeny of Klebsiella pneumoniae OXA-48 Class D carbapenemases