EZH2 targeting to improve the sensitivity of acquired radio-resistance bladder cancer cells

Translational Oncology(2022)

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摘要
•Fractionated irradiation enriched stem cell-like characteristics and increased EZH2 expression of BCa cells.•Down-regulation of EZH2 reduced the radio-resistance phenotype and decreased the microsphere formation and DNA repair abilities of BCa cells.•Down-regulation of EZH2 affected the autophagic-flux stability of BCa cells.•Down-regulation of EZH2 inhibited ARR cells growth in vivo.
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关键词
Bladder cancer,Acquired radio-resistance,EZH2,Radiosensitivity,Autophagy
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