MRA of the Supraaortic Vasculature: Comparison of Gadobutrol and Gadoterate Meglumine at 1.5 T

JOURNAL OF MAGNETIC RESONANCE IMAGING(2022)

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摘要
Background Gadobutrol (GB) and gadoterate meglumine (GM) are contrast agents used for contrast-enhanced magnetic resonance angiography (CEMRA). Supraaortic vasculature (SAV) CEMRAs are used to evaluate stroke risk and neurologic symptoms. There is a need to compare the SAV CEMRA image quality obtained with GB and GM. Purpose To intra-individually compare MRA images obtained with equimolar GB and GM at 1.5 T in the SAV. Study Type Prospective, crossover. Population Twenty-eight subjects (54 +/- 13 years; 17 female). Field Strength/Sequence 1.5 T; three-dimensional (3D) gradient recalled echo. Assessment Quantitative image quality was measured by normalized signal intensity (SIn) [SIn = SI blood/SD blood] and contrast ratio (CR) [CR = SI blood/SI muscle], determined by an observer (JWC) with 1 year of vascular imaging experience. Three radiologists (AS, PA, and MU) with (5, 5, and 6 years of) vascular imaging experience evaluated image quality by Likert-scale ratings (of image impression, wall conspicuity, and artifact absence). Statistical Tests SIn and CR were compared with paired t-tests or Wilcoxon signed-rank tests and Bland-Altman plots. Qualitative ratings were compared with Wilcoxon signed-rank test. Results No significant difference in SIn was found between GB and GM. CRs with GB were significantly higher than GM at the right common carotid (6.9 +/- 2.5 vs. 4.8 +/- 1), left internal carotid (7.3 +/- 2 vs. 4.4 +/- 1.2), right internal carotid (7.7 +/- 2.2 vs. 5 +/- 1.1), and left vertebral (6.6 +/- 2.2 vs. 4.5 +/- 1.1) arteries. Bland-Altman plots showed relatively greater differences between GB and GM at higher CRs and SI(n)s. GM showed significantly higher artifact than GB (3.56 +/- 0.52 vs. 3.36 +/- 0.46) and significantly lower overall image quality (10.73 +/- 1.45 vs. 11.26 +/- 1.58) at the left vertebral artery. Data Conclusion At 1.5 T and equimolar demonstration, GB (0.1 mL/kg, i.e., 0.1 mmol/kg) showed higher CRs in the SAV compared to GM (0.2 mL/kg, i.e., 0.1 mmol/kg) at most vessels. Subjective image quality was not significantly different between the two agents for most vessels. Level of Evidence 2 Technical Efficacy Stage 2
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关键词
supraaortic vasculature, gadobutrol, gadoterate meglumine
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