Title: Deletion of the von Hippel-Lindau gene in hemangioblasts causes hemangioblastoma-like lesions in murine retina Running title: Vhl deletion in mouse hemangioblasts causes RCH-like lesions

Author affiliations: 1 Neuro-Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, U.S.A. 2 Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, U.S.A. 3 National Eye Institute, National Institutes of Health, Bethesda, Maryland, U.S.A. 4 Department of Orthopedics; Xinqiao Hospital; Third Military Medical University; Chongqing, China 5 State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China 6 Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, U.S.A. 7 Department of Neurologic Surgery, University of Virginia Health System, Charlottesville, Virginia, U.S.A 8 Corresponding authors: Chi-Chao Chan BG10 RM 10S247 10 CENTER DR BETHESDA, MD, 20892-1857 chanc@nei.nih.gov