Reply:

1) John BV, Aitcheson G, Schwartz KB, Shabbir Khakoo N, Dahman B, Deng Y, et al. Male sex is associated with higher rates of liverrelated mortality in primary biliary cholangitis and cirrhosis. Hepatology 2021;74:879-891. 2) Lleo A, Wang GQ, Gershwin ME, Hirschfield GM. Primary biliary cholangitis. Lancet 2020;396:19151926. 3) Corpechot C, Gaouar F, Chrétien Y, Johanet C, Chazouillères O, Poupon R, et al. Smoking as an independent risk factor of liver fibrosis in primary biliary cirrhosis. J Hepatol 2012;56:218224. 4) Zein CO, Beatty K, Post AB, Logan L, Debanne S, McCullough AJ, et al. Smoking and increased severity of hepatic fibrosis in primary biliary cirrhosis: a cross validated retrospective assessment. Hepatology 2006;44:15641571.