A generic liquid chromatography-mass spectrometry method for monitoring bis(pinacolato)diboron mutagenic impurity in pharmaceutical compounds

Ziqing Lin,Hua-Chia Tai,Emanuele Petruzzella, Feili Tang,Yun K. Ye,James Chadwick,Wei Ding,Brian Lingfeng He,Scott A. Miller

Journal of Chromatography Open（2021）

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摘要

•Developed a generic LC-MS method for trace B2Pin2 quantification.•Eliminated MS detection variances by forming B2Pin2 ammonium adduct ion.•Optimized LC-MS conditions free of interferences from diluents or substrates.•Studied sample preparation procedures to ensure B2Pin2 solution stability.•Achieved B2Pin2 recoveries within 100 ± 20% at 1–20 ppm in three cases.

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关键词

B2Pin2,Mutagenic impurity,LC-MS,Gas-phase ion manipulation,Solution stability

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