Association between periodontal disease and coronary heart disease risk in Chinese population: evidence from a meta-analysis

Aims More and more research is focused on studying the relationship of periodontal disease with susceptibility to coronary heart disease (CHD), among which discrepancies have risen. The current study aimed to evaluate the possible relationship about periodontal disease and CHD in certain Chinese population. Methods The PubMed, Embase, Web of Science, the Cochrane Library, the Chinese Biomedical Database, and the Chinese National Knowledge Infrastructure were searched up to December 2018. The overall and subgroup analyses were performed using fixed or random-effect model depending on heterogeneity. Results A total of 2241 CHD cases and 2160 in 15 studies were used in the current study. Overall, a significantly elevated relationship about periodontal disease on CHD risk was found in all included Chinese subjects (OR=3.04, 95% CI, 2.37-3.92). Subgroup analyses by geographic location and sources of control were also performed; all the results in subgroup analyses were consistent with the overall result. Meanwhile, the significant association was found among the measures of periodontal disease with attachment loss, periodontal index, two or more clinical indications, and gum recession as well as CHD assessment method with WHO criteria and coronary arteriongraphy. Conclusions Collectively, the meta-analysis indicated that periodontal disease was capable of causing CHD susceptibility among Chinese.