Monodisperse Polysarcosine-Based Antibody-Drug Conjugates

We report the on-resin synthesis of monodisperse (i.e. discrete) polysarcosine compounds and their use as an hydrophobicity masking entity for the construction of highly-loaded homogeneous antibody-drug conjugates (ADC). The polysarcosine-based drug-linker platform described herein improves drug-loading, physicochemical properties, pharmacokinetics and shows excellent potency in vivo.