Lipid Bilayer-Coated Mesoporous Silica Nanoparticles Carrying Bovine Hemoglobin as 1 an Erythrocyte Mimic 2 3

1 Lipid Bilayer-Coated Mesoporous Silica Nanoparticles Carrying Bovine Hemoglobin as 1 an Erythrocyte Mimic 2 3 Jing Tu 1, Jeroen Bussmann 1, 2, Guangsheng Du 3, Yue Gao 1, Joke A. Bouwstra 3, Alexander 4 Kros 1* 5 6 1Department of Supramolecular & Biomaterials Chemistry, Leiden Institute of Chemistry 7 (LIC), Leiden University, P.O. Box 9502, 2300 RA Leiden, The Netherlands 8 9 2Leiden Institute of Biology, Gorlaeus Laboratories, Leiden University, P.O. Box 9502, 10 Leiden, 2300 RA, The Netherlands 11 12 3Division of Drug Delivery Technology, Cluster BioTherapeutics, Leiden Academic Centre 13 for Drug Research (LACDR), Leiden University, P.O. Box 9502, 2300 RA Leiden, The 14 Netherlands 15 16 *Corresponding Author. 17 Dr Alexander Kros: E-mail: a.kros@chem.leidenuniv.nl 18 19 20 21 22