Phytochemical Screening and Evaluation of Thrombolytic, Analgesic and Antidiarrhoeal Activity of the Leaves of Cucumis sativus Linn. (Cucurbitaceae) of Methanolic Extracts

Aims: The present study was performed to evaluate the phytochemical screening of compounds, thrombolytic activity, analgesic activity and antidiarrhoeal activity of the methanolic extract of of Cucumis sativus Linn. (Cucurbitaceae) leaves. Background: Cucumis sativus Linn. is generally disseminated all through the world especially in Asia, Africa and South America. Locally the plant is utilized for basic role of cerebral pain, the seed is utilized for diuretic and cooling purposes. The leaf sap is emetic, it is utilized for treating dyspepsia in children. Methods: The thrombolytic activity was evaluated by using clot lysis method. Analgesic activity was investigated using writhing method in mice and anti-diarrhoeal activity test was performed castor oil-induced diarrhoea in mice as well. Result: Significant thrombolytic activity was found for Cucumis sativus Linn 100mg plant leaves extract (29.33%) clot lysis in respect of positive control streptokinase (30000 IU) was shown 65.26% clot lysis. Analgesic activity was investigated using writhing method at the doses of 250/kg and 500 mg/ kg body weight and found 54.72 % and 55.66 % of inhibition respectively compared to standard Diclofenac Na (76.41 %) writhing inhibition. Anti-diarrhoeal activity test was performed at the dose of 500 mg/kg body weight (PO) against castor oil-induced diarrhoea and % of inhibition of feces was found about 62.5% respectively. Conclusion: Cucumis sativus Linn. was shown significant pharmacological potentiality in various study model which will helpful for further studies.