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Development of a Practical Manufacturing Process to Relebactam Via Thorough Understanding of the Origin and Control of Oligomeric Impurities

Jungchul Kim,Tetsuji Itoh,Feng Xu,Zachary E. X. Dance,Jacob H. Waldman,Debra J. Wallace, Feiyue Wu,Roman Kats-Kagan,Anil R. Ekkati,Andrew P. J. Brunskill,Feng Peng,Patrick S. Fier,Jennifer Obligacion,Benjamin D. Sherry,Zhijian Liu,Khateeta M. Emerson,Adam J. Fine,Anna Jenks,Marco Euclide Armenante

Organic Process Research & Development（2021）

引用 3|浏览23
关键词
relebactam,oligomers,hydrogenolysis,sulfation,SO3 center dot triethylamine,bromotrimethylsilane
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