Productivity for free: Residence time gradients during loading increase dynamic binding capacity and productivity
Separation and Purification Technology(2022)
摘要
•An algorithm to improve productivity and dynamic binding capacity in protein chromatography.•A controller to optimize the flow rate gradient during loading.•The theoretical concept has been validated by chromatography experiments.•The algorithm allows a productivity increase of 68% in Protein A chromatography without additional expense.
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关键词
Productivity,Resin utilization,mAb,Optimization,Process simulation
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