Interplay of sex hormones and long-term right ventricular adaptation in a Dutch PAH-cohort

Jessie van Wezenbeek,Joanne A. Groeneveldt,Aida Llucià-Valldeperas,Cathelijne E. van der Bruggen,Samara M.A. Jansen,A. Josien Smits,Rowan Smal, Joost W. van Leeuwen,Cris dos Remedios,Anne Keogh,Marc Humbert,Peter Dorfmüller,Olaf Mercier,Christophe Guignabert,Hans W.M. Niessen,M. Louis Handoko,J. Tim Marcus,Lilian J. Meijboom,Frank P.T. Oosterveer,Berend E. Westerhof

The Journal of Heart and Lung Transplantation（2022）

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摘要

Sex hormones are differently associated with RV function in male and female PAH-patients. DHEA-S appeared to be lower in male and female PAH-patients. Females ≤45years could persevere pressure-overload for a longer time, but had a more severe RV phenotype at end-stage disease.

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