Controllable release of vascular endothelial growth factor (VEGF) by wheel spinning alginate/silk fibroin fibers for wound healing

•Wheel spinning technique was used to produce wet spun alginate composite fibers.•Alginate/silk fibroin morphologies and concentrations control vascular endothelial growth factor release.•The design of experimental factors and interactions address release mechanisms.•Non-linear fitting was introduced to describe vascular endothelial growth factor release behavior.