Identification of unique bile acid-metabolizing bacteria from the 1 microbiome of centenarians 2 3

Identification of unique bile acid-metabolizing bacteria from the 1 microbiome of centenarians 2 3 Yuko Sato1,3,5,§, Koji Atarashi1,3,5,§, Damian R. Plichta4,§, Yasumichi Arai2, Satoshi Sasajima1,5, Sean M. 4 Kearney1,3, Wataru Suda3, Kozue Takeshita1,5, Takahiro Sasaki6, Shoki Okamoto1, Ashwin N. Skelly1, Yuki 5 Okamura1, Hera Vlamakis4, Youxian Li3, Takeshi Tanoue1,3,5, Hajime Takei7, Hiroshi Nittono7, Seiko 6 Narushima1,3, Junichiro Irie8, Hiroshi Itoh8, Kyoji Moriya9, Yuki Sugiura10, Makoto Suematsu10, Nobuko 7 Moritoki11, Shinsuke Shibata11, Dan R. Littman12,13, Michael A. Fischbach14, Masahira Hattori3, Tsuyoshi 8 Murai6, Ramnik J. Xavier4,15, Nobuyoshi Hirose2, Kenya Honda1,3,5,* 9