Bile duct ligation increased dopamine levels in the cerebral cortex of rats partly due to induction of tyrosine hydroxylase.

Weimin kong, Xueying Sun, Siyu Yu,Peihua Liu,Xiaoke zheng,Jiaxin Zhang,Liang Zhu,Tianxin Jiang,Mengmeng Jin, Jinghui Gao,XiaoDong Liu,Li Liu

British journal of pharmacology（2023）

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摘要

BDL significantly increased dopamine levels in rat cortex partly due to bilirubin-mediated TH induction. Increased bilirubin induced TH expression via activating NF-κB signaling pathway.

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关键词

bilirubin,dopamine,hepatic encephalopathy,liver failure,tyrosine hydroxylase

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