Cu-Based Turn-on Fluorescent Sensors for Cu-rich Amyloid β Aggregates

Protein misfolding and metal dishomeostasis are two keypathological factors of Alzheimer’s disease. Previous studies have showed that Cu‐mediated Aβ aggregation pathways lead to formation of neurotoxic Aβ oligomers. Herein, we reported a series of picolinic acid‐based Cu‐activatable sensors, which can be used for the fluorescence imaging of Cu‐rich Aβ aggregates.