Histamine 2 receptors in cardiovascular biology: A friend for the heart

Sherin Saheera,Ajay Godwin Potnuri,Ashrith Guha,Suresh S. Palaniyandi,Rajarajan A. Thandavarayan

Drug Discovery Today（2022）

引用 7|浏览4

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摘要

•Mast cells are important mediators in cardiovascular diseases.•The mast cell mediator, histamine is involved in cardiovascular pathophysiology.•Histamine receptors are better target for treating cardiovascular therapies.•Antihistamines have been used widely in preclinical and clinical studies for CVDs.•Repurposing of H2 receptor antagonists will aid in better adjuvant therapies for CVDs.

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关键词

Cardiovascular disease,Inflammation,Mast cell,Histamine,Histamine receptor,Histamine 2 receptor,Histamine antagonists,Antihistamines

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