Characterization of an Acute Myeloid Leukemia Murine Model Driven By MLL/AF9: Effect of Retroviral Insertion Sites and Somatic Mutations on Gene Expression

Hui Mei Lee,Niloofar Zandvakili,Rhea Desai,Peter J. Browett,Purvi M Kakadia,Stefan K. Bohlander

Blood（2021）

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摘要

The MLL/AF9 fusion is found in approximately 30% of MLL-rearranged leukemias and has an intermediate prognosis. Genomically well-characterized murine leukemia models enable us to understand leukemogenesis.

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