Thromboembolism, Bleeding, and Vascular Death Among Older and Younger Nonvalvular Atrial Fibrillation Patients with Type 2 Diabetes Receiving Rivaroxaban or Warfarin

Background: Advancing age and diabetes are common comorbidities among patients diagnosed with nonvalvular atrial fibrillation (NVAF). In separate subanalyses of the Rivaroxaban Once Daily, Oral, Direct Factor Xa Inhibition Compared With Vitamin K Antagonism for Prevention of Stroke and Embolism Trial in Atrial Fibrillation (ROCKET AF), the relative efficacy and safety of rivaroxaban versus warfarin did not vary with by older (≥75 years old) or younger age (<75 years old) or with the presence or absence of diabetes. We sought to evaluate the impact of age on the comparative effectiveness and safety of rivaroxaban compared to warfarin in NVAF patients with comorbid diabetes treated in routine practice