B Cell Transcriptional Coactivator POU2AF1 (BOB-1) Is an Early Transcription Factor Modulating the Protein Synthesis and Ribosomal Biogenesis in Multiple Myeloma: With Therapeutic Implication

Zuzana Chyra,Mehmet K. Samur,Anil Aktas-Samur, Yao Yao,Sanika Derebail,Tommaso Perini,Yan Xu,Eugenio Morelli, Sophia Adamia,Woojun D Park,Lin Charles,Ryosuke Shirasaki,Masood A. Shammas,Constantine S. Mitsiades,Roman Hajek,Mariateresa Fulciniti,Nikhil C. Munshi

Blood（2021）

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摘要

Multiple Myeloma (MM) is a malignancy driven by numerous genetic and epigenetic alterations. Recurrent IgH translocations, somatic mutations and copy number abnormalities all contribute to myelomagenesis, however true drivers of the disease have not been well defined.

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