SARS-CoV-2 Immunohistochemistry In Placenta.

Dinesh Rakheja, Kristina Treat,Charles F Timmons, Deyssy Carrillo,Sara E Miller,Edana Stroberg,Lisa M Barton,Eric J Duval,Sanjay Mukhopadhyay

INTERNATIONAL JOURNAL OF SURGICAL PATHOLOGY（2021）

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摘要

Compared to the parental SARS-CoV-2 virus, infections by the now dominant Delta variant of SARS-CoV-2 appear to be more common and more severe in pregnant women. The need for a robust, cheap, and quick method for diagnosing placental infection by SARS-CoV-2 has thus become more acute. Here, we describe a highly sensitive and specific immunohistochemical assay for SARS-CoV-2 nucleocapsid protein for routine use in placental pathology practice.

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关键词

SARS-CoV-2, COVID-19, immunohistochemistry, nucleocapsid protein, spike protein, placenta, electron microscopy, ultrastructure

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